A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature (2024)

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Data availability Code availability References Acknowledgements Author information Authors and Affiliations Contributions Corresponding authors Ethics declarations Competing interests Peer review Peer review information Additional information Supplementary information Supplementary Information Reporting Summary Supplementary Video 1 Source data Source Data Fig. 2 Source Data Fig. 3 Source Data Fig. 4 Source Data Fig. 5 Source Data Fig. 6 Rights and permissions About this article Cite this article

Data availability

The main data supporting the results in this study are available within the paper and its Supplementary Information. Source data for Figs. 2–6 are provided with this paper. The raw and analysed datasets generated during the studies are too large to be publicly shared, yet they are available for research purposes from the corresponding author on reasonable request. Source data are provided with this paper.

Code availability

Custom-developed firmware for BLE SoCs and Android applications (UIs) for use on smartphones are available from the corresponding author on reasonable request. All requests for source code will be reviewed by the corresponding author to verify whether the request is subject to any intellectual property or confidentiality obligations.

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Acknowledgements

K.K. acknowledges support by the National Research Foundation (NRF) grant funded by the Korea government (MSIP; Ministry of Science, ICT & Future Planning; no. 2021R1F1A106387111, no. 2022R1C1C1010555 and no. 2020R1A5A8018367). J.U.K. and T.K. were supported by the NRF funded by the Korean government (MSIT; NRF-2019M3C7A1032076 and NRF-2020M3H4A1A03082897). S.M.W. acknowledges support by the NRF grant funded by the Korea government (MSIP, ICT & Future Planning; no. NRF-2021R1C1C1009410 and no. IITP-2020-0-01821). R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF grant number DGE-1842165) and Ford Foundation Predoctoral Fellowship. J.A.R. acknowledges support from the National Institute on Aging of the National Institutes of Health (NIH R43AG067835). We acknowledge funding from Wearifi Inc., and the Querrey-Simpson Institute for Bioelectronics at Northwestern University for support of this work. This work made use of the NUFAB facility of Northwestern University’s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the MRSEC programme (NSF DMR-1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation and the State of Illinois, through the IIN.

Author information

Author notes

See Also
Best Blood Pressure Monitors in 2024: Reviewed by Our Experts

  1. These authors contributed equally: Kyeongha Kwon, Jong Uk Kim, Sang Min Won, Jianzhong Zhao.

Authors and Affiliations

  1. School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

    Kyeongha Kwon

  2. School of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea

    Jong Uk Kim&Tae-il Kim

  3. Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA

    Jong Uk Kim,Seonggwang Yoo,Joohee Kim,Jaeman Lim,Wei Lu,Anthony Banks,Yonggang Huang&John A. Rogers

  4. Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Republic of Korea

    Sang Min Won

  5. Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing, China

    Jianzhong Zhao,Heling Wang&Yonggang Huang

  6. Department of Civil and Environmental Engineering, Materials Science and Engineering, Northwestern University, Evanston, IL, USA

    Jianzhong Zhao,Heling Wang&Yonggang Huang

  7. Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA

    Jianzhong Zhao,Heling Wang&Yonggang Huang

  8. Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA

    Jianzhong Zhao,Raudel Avila&Heling Wang

  9. Electrical and Computer Engineering, the University of Texas at Austin, Austin, TX, USA

    Keum San Chun

  10. Department of Electrical & Computer Engineering, University of Wisconsin, Madison, WI, USA

    Hokyung Jang

  11. ImpriMED, Inc., Palo Alto, CA, USA

    Kun Hyuck Lee

  12. Department of Electrical and Computer Engineering, University of Illinois at Urbana–Champaign, Urbana, IL, USA

    Jae-Hwan Kim

  13. Department of Ocean System Engineering, Jeju National University, Jeju, Republic of Korea

    Youn J. Kang

  14. Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Republic of Korea

    Yoonseok Park

  15. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Republic of Korea

    Tae-il Kim

  16. Wearifi, Inc., Evanston, IL, USA

    Anthony Banks&John A. Rogers

  17. Department of Biomedical Engineering, Neurological Surgery, Chemistry, Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, USA

    John A. Rogers

Authors

  1. Kyeongha Kwon

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  2. Jong Uk Kim

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  3. Sang Min Won

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  4. Jianzhong Zhao

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  5. Raudel Avila

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  6. Heling Wang

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  7. Keum San Chun

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  8. Hokyung Jang

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  9. Kun Hyuck Lee

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  10. Jae-Hwan Kim

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  11. Seonggwang Yoo

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  12. Youn J. Kang

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  13. Joohee Kim

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  14. Jaeman Lim

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  15. Yoonseok Park

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  16. Wei Lu

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  17. Tae-il Kim

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  18. Anthony Banks

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  19. Yonggang Huang

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  20. John A. Rogers

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Contributions

K.K. and J.A.R. conceived the idea and designed the research. K.K., J.U.K. and J.A.R. analysed data and wrote the manuscript. K.K. designed the hardware for the wireless electronic system. K.K. and K.S.C. performed software design and software validation. J.U.K. and S.M.W. performed and were involved in the manufacturing of the sensor modules. J.Z., R.A., H.W. and Y.H. performed mechanical modelling. K.K. and J.U.K. performed research and led the experimental works with support from H.J., K.H.L., J.-H.K., S. Y., Y.J.K., J.K., J.L., Y.P., W.L., T.K. and A.B.

Corresponding authors

Correspondence to Kyeongha Kwon or John A. Rogers.

Ethics declarations

Competing interests

A.B. and J.A.R. are co-founders of Hemorhythmics Inc., which has potential commercial interest in the technology described in this work. A.B. and J.A.R. are co-founders of the company. A.B is an employee of Wearifi Inc., which may wish to pursue commercialization of this technology in future. The other authors declare no competing interests.

Peer review

Peer review information

Nature Biomedical Engineering thanks Jun Chen and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Supplementary Information

Supplementary notes, figures and references.

Supplementary Video 1

Movement of the sensing module inside the PA of porcine hearts recorded by a borescope.

Source data

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A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature (1)

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Kwon, K., Kim, J.U., Won, S.M. et al. A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature. Nat. Biomed. Eng 7, 1215–1228 (2023). https://doi.org/10.1038/s41551-023-01022-4

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  • DOI: https://doi.org/10.1038/s41551-023-01022-4

A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature (2024)
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